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目的:探讨细菌内毒素检查法限值的计算可能存在的问题。方法:将细菌内毒素稀释成不同浓度,分别静脉注射各组家兔,记录各组家兔体温变化并进行线性回归。结果:家兔体温升高值与注射的细菌内毒素浓度呈相关性。结论:热原检查与细菌内毒素检查的结果判断存在差异,细菌内毒素检查法限值的计算有待进一步探讨。
Objective: To explore the possible problems in the calculation of limit value of bacterial endotoxin test. Methods: Bacterial endotoxin was diluted into different concentrations and rabbits in each group were intravenously injected. The changes of body temperature in rabbits in each group were recorded and linear regression was performed. Results: The increase of body temperature in rabbits was correlated with the concentration of bacterial endotoxin injected. Conclusion: There are differences in the results of pyrogen test and bacterial endotoxin test, and the calculation of bacterial endotoxin test limit needs to be further explored.