一、引言染色体异常在肿瘤发生发展过程有何意义?至今仍不很清楚。但是,大多数癌细胞都有染色体畸变。这个现象早已成为众所周知的事实。许多试验证明,自然环境中物理、化学和生物因素都可以引起染色体损伤,而这些损伤又可以在癌的演进过程中得到发展。这三类环境致突变-致癌物对染色体的损伤都 I. INTRODUCTION What is the significance of chromosomal abnormalities in the development of tumors? It is still not clear. However, most cancer cells have chromosomal aberrations. This phenomenon has long been a well-known fact. Many experiments have shown that physical, chemical, and biological factors can cause chromosomal damage in the natural environment, and these injuries can develop during the evolution of cancer. These three types of environmental mutagenesis-carcinogens all cause chromosome damage