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目的:格林-巴利综合征(GBS)病因及发病机制探讨。方法:ELISA法测定49例GBS病人血清抗空肠弯曲菌抗体(Cj-Ab)及GM_1-IgG抗体,并与临床严重程度、预后、电生理进行相关分析。结果:GBS组血清Cj-IgA、IgG,GM_1-IgG阳性率与对照组存在显著差异,而GBS组血清Cj抗体、GM_1抗体与临床严重程度、预后及电生理均无相关性。结论:Cj近期感染与GBS发病相关;GBS病人血清GM_1-IgG亦有显著升高,但与Cj感染无关,可能只是一种神经损害后继发免疫改变,反对Yuki关于Cj感染后自身免疫引起GBS学说。
Objective: To explore the etiology and pathogenesis of Guillain-Barre Syndrome (GBS). Methods: The serum anti-Cj-Ab and GM-IgG antibodies of 49 patients with GBS were measured by ELISA. The correlation was analyzed with clinical severity, prognosis and electrophysiology. Results: The positive rates of serum Cj-IgA, IgG and GM_1-IgG in GBS group were significantly different from those in control group. Serum Cj antibody and GM_1 antibody in GBS group had no correlation with clinical severity, prognosis and electrophysiology. Conclusion: The recent infection of Cj is related to the pathogenesis of GBS. The serum GM_1-IgG of GBS patients is also significantly increased, but not related to Cj infection, it may be only a secondary immune change after nerve injury, and objection to Yuki’s autoimmune-induced GBS doctrine after Cj infection .