目的探讨多发性硬化周围神经功能改变电生理特点分析。方法选择我院收治的MS患者50例,采用神经电生理技术评价(观察组);就临床资料与健康志愿者50例(对照组)的检测结果行对比分析。结果对照组均做双侧腓神经、胫神经、尺神经、正中神经检测,共测出以上神经各100条。观察组以上项目检测37例,共测出以上神经各74条。NCV在观察组患者中均有程度不等的减慢表现,与SCV比较,MCV的异常率较高,轴突损害经NCV结果显示,比脱髓鞘明显。采用MEP测得的腰4点和肘点在潜伏期上相对延长,故腰骶神经根功能和正中神经远端功能可能受到损害。患者中部分F波在出现率方面有所降低,表明周围神经根有异常表现。结论多发性硬化周围神经功能改变采用电生理检测,可显著提高检测准确率,为临床治疗创造条件。 Objective To investigate the electrophysiological characteristics of peripheral nerve changes in multiple sclerosis. Methods 50 cases of MS patients admitted to our hospital were evaluated by electrophysiological technique (observation group). The clinical data and healthy volunteers were compared in 50 cases (control group). Results The control group were done bilateral peroneal nerve, tibial nerve, ulnar nerve, median nerve test, a total of 100 nerves were measured. In the observation group, 37 cases were detected by above items, and 74 of the above nerves were detected. NCV in the observation group of patients with varying degrees of slowing performance, compared with the SCV, MCV abnormalities higher rates of axonal damage by NCV results, significantly more than demyelination. The lumbar sacral nerve root function and the distal nerve function of the median nerve may be impaired by the 4-point lumbar and elbow point measured by MEP in the relatively prolonged incubation period. F-wave in patients with part of the frequency decreased, indicating that peripheral nerve root abnormalities. Conclusion The changes of peripheral nerve function in multiple sclerosis using electrophysiological examination can significantly improve the detection accuracy and create conditions for clinical treatment.