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慢性乙型肝炎严重危害人类健康,但目前尚缺乏满意的治疗药物。西药治疗慢性乙型肝炎疗效不甚理想且费用高、副作用大,中西医结合治疗正受到越来越多的关注和研究。文章评价了中医药能否提高西药治疗慢性乙型肝炎的疗效,降低其不良反应。检索策略:1.电子检索:以中西医结合、中西药结合、中医药、中成药和慢性乙型肝炎等为主题词或自由词,检索中国期刊网,Medline、中国生物医学光盘数据库(CBM),Cochrane肝胆病组临床试验资料库等电子数据库。2.手工检索30种中医杂志及有关学术论文汇编,鉴定相关文献的参考文献作为补充检索。纳入标准:所有研究中西药结合与单用西药治疗慢性乙型肝炎的随机对照研究,其中中药必须是国家正式批准文号的或有省级制剂批准文号的药品,并且干预组与对照组西药相同。评价方法:参照Cochrane系统评价的要求,对选择纳入的临床试验进行方法学质量的评估,数据的提取和Meta分析。
Chronic hepatitis B seriously endangers human health, but there is a lack of satisfactory therapeutic drugs. Western medicine treatment of chronic hepatitis B less than ideal and costly, side effects, integrated Chinese and Western medicine treatment is receiving more and more attention and research. The article evaluates whether traditional Chinese medicine can improve the curative effect of western medicine on chronic hepatitis B and reduce its adverse reactions. Search strategy: 1.Electronic retrieval: search Chinese Journal Net, Medline, China Biomedical Optical Disk Database (CBM) with Chinese and western medicine, traditional Chinese medicine and western medicine, traditional Chinese medicine, proprietary Chinese medicine and chronic hepatitis B as keywords or free words, , Cochrane hepatobiliary disease clinical trial database and other electronic databases. 2. Manual search of 30 kinds of Chinese magazines and related academic papers compiled, identification of relevant literature reference as a supplementary search. Inclusion criteria: All the study of Western medicine combined with Western medicine alone for the treatment of chronic hepatitis B, a randomized controlled study, which must be the official Chinese medicine approval number or provincial approval number of the preparation of drugs, and the intervention group and the control group of Western medicine the same. Evaluation method: According to the requirements of Cochrane Systematic Review, methodological quality assessment, data extraction and meta-analysis of selected clinical trials were performed.