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在粟粒性结核病中,最常见的血液异常为贫血,但中性粒细胞减少和全血细胞减少,特别在无反应型粟粒性结核也经常发生。早先报导该型疾病往往会致命,但目前有些病人对化疗产生良好效果。一些学者提出脾功能亢进可能是一发病因素.分枝杆菌或宿主炎症性免疫反应对骨髓的毒性作用也可能存在。Bagby 等报告2例播散性分枝杆菌感染伴全血细胞减少症患者,在体外作骨髓功能测定。培养患者骨髓细胞,7天后计数粒细胞-巨噬细胞的生长集落。也作了实验性骨髓单核-巨噬细胞或 T 淋巴细胞的清除试
In miliary tuberculosis, the most common blood disorder is anemia, but neutropenia and pancytopenia, especially in non-reactive miliary tuberculosis, also occur frequently. Earlier reports of this type of disease are often fatal, but some patients present with good results on chemotherapy. Some scholars have suggested that hypersplenism may be a causative agent.Myotoxicity of mycobacterium or host inflammatory response to bone marrow may also exist. Bagby et al reported 2 cases of disseminated mycobacterial infection with pancytopenia in vitro for bone marrow function tests. Patient bone marrow cells were cultured, and the growth colonies of granulocyte-macrophages were counted after 7 days. Experimental bone marrow monocyte-macrophage or T lymphocyte clearance tests were also performed