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目的:探讨尿系列微量蛋白检测在儿童(<13岁)肾脏损伤中的意义。方法:选取尿路感染患儿60例、急性肾小球肾炎患儿60例、过敏性紫癜性肾炎患儿70例、原发性肾病综合征患儿80例及正常儿童30例,采用速率散射比浊法检测尿微量白蛋白、免疫球蛋白G、α1-微球蛋白、转铁蛋白含量,采用微粒子酶免法检测尿β2-微球蛋白含量。结果:除急性肾小球肾炎组的α1-M,尿路感染组的IgG、α1-M、TRF与正常对照组比较差别无统计学意义(P(0.05)外,各组别其余项目与正常对照组比较差别均有统计学意义(除过敏性紫癜性肾炎组的α1-MP<0.05外,其余均P<0.01);117例尿蛋白定性阴性的患儿尿系列微量蛋白检出阳性47例,阳性率为36.75%。结论:尿系列微量蛋白测定可用来判断儿童早期肾损害。
Objective: To investigate the significance of urinary trace protein detection in children with kidney injury (<13 years old). Methods: Sixty children with urinary tract infection, 60 children with acute glomerulonephritis, 70 children with allergic purpura nephritis, 80 children with primary nephrotic syndrome and 30 normal children were enrolled in this study. Urine microalbumin, immunoglobulin G, α1-microglobulin and transferrin were detected by turbidimetric method. Urine β2-microglobulin content was detected by microparticle enzyme immunoassay. RESULTS: Except α1-M in acute glomerulonephritis group and IgG, α1-M and TRF in urinary tract infection group, there was no significant difference between normal group and control group (P <0.05) There were significant differences in the control group (except α1-MP <0.05 in allergic purpura nephritis group, all other P <0.01); in 117 cases with negative urine protein, the urine micro-protein was positive in 47 cases , The positive rate was 36.75% .Conclusion: The determination of urine trace protein can be used to determine the early childhood renal damage.