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据报道中性白细胞减少症患者在使用氨基糖苷类抗生素时,连续静滴给药的疗效比间歇给药方法好。有人发现在丁胺卡那霉素的用药过程中,对血药浓度已经达到稳态的病人,在不同时间采集的血样,所测得的血药浓度往往有较大的波动。作者研究了丁胺卡那霉素的这一昼夜节律变化。受试者为50例中性白细胞减少症病人,肾功能均在正常范围。试验采用自身对照方案,将受试者随机分组后,静脉滴注单一的了胺卡那霉素,或将丁胺卡那霉素与 Cefta-zidime,或 Imipenem 联用,丁胺卡那霉素连续滴注的日剂量均为800mg/m~2,待血清丁胺卡那霉素浓度达到稳态以后,每日3次
It has been reported that neutropenic patients in the use of aminoglycoside antibiotics, continuous intravenous administration than intermittent administration. It has been found in the amikacin medication, the plasma concentration has reached steady-state patients, blood samples collected at different times, the measured plasma concentration tends to have greater volatility. The authors studied this circadian variation of amikacin. The subjects were 50 patients with neutropenia, renal function are in the normal range. Patients were randomly assigned to receive either a single amikacin intravenous infusion or amikacin plus Ceftazidime or Imipenem plus amikacin The continuous daily dose of drip is 800mg / m ~ 2, until the serum amikacin concentration reached steady state, 3 times a day