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目的比较两种类型创面病原菌定植和感染的差异性,为临床防治提供理论依据。方法通过创面分泌物细菌培养、鉴定以及药敏试验,观察比较某医院烧伤整形外科住院患者不同创面病原菌定植感染特征。结果从两种类型创面采集分泌物494例次,分离出病原菌368株,其中多重耐药菌258株,占检出总菌数的70.11%。难愈性创面分泌物中病原菌检出率为85.23%,其中多重耐药菌比例为75.85%,以革兰阴性菌为主;非难愈性创面分泌物中病原菌检出率为51.56%,多重耐药菌比例为55.34%,以革兰阳性菌为主。多因素Logistic回归分析显示。住院史和本次住院超过2周是难愈性创面病原菌定植感染的独立危险因素。结论难愈性创面分泌物病原菌检出率、多重耐药菌比例均高于非难愈性创面,必须加强难愈性创面消毒等防控措施,降低病原菌定植率。
Objective To compare the differences of colonization and infection between two types of wound pathogens and provide a theoretical basis for clinical prevention and treatment. Methods Bacterial culture, identification and susceptibility testing of wound secretions were performed to observe the characteristics of colonization infection of pathogenic bacteria in different wounds in a hospital burn burn patients. Results A total of 494 cases of secretions were collected from two types of wounds. 368 strains of pathogens were isolated, of which 258 were multi-drug resistant strains, accounting for 70.11% of the total. The detection rate of pathogenic bacteria in refractory wounds was 85.23%, of which 75.85% were multi-drug resistant strains. Gram-negative bacteria were the main pathogens. The detection rate of non-refractory wound secretions was 51.56% Drug-bacteria ratio was 55.34%, mainly to Gram-positive bacteria. Multivariate logistic regression analysis showed. Hospitalization and hospitalization for more than 2 weeks were independent risk factors for venereal wound infection of refractory wounds. Conclusions The detection rate of pathogenic bacteria of refractory wound secretions and the proportion of multi-drug resistant bacteria are higher than that of non-refractory wounds. Prevention and control measures such as disinfection of refractory wounds should be strengthened to reduce the colonization rate of pathogenic bacteria.