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目的比较阿昔洛韦和泛昔洛韦治疗带状疱疹的临床疗效。方法选取永顺县皮肤病性病防治所2012年8月—2014年8月收治的带状疱疹患者80例,根据随机数字表法将患者分为阿昔洛韦组与泛昔洛韦组,各40例。两组患者均给予物理治疗、维生素B1、B12及外敷云南白药常规治疗。阿昔洛韦组给予阿昔洛韦片治疗,泛昔洛韦组给予泛昔洛韦片治疗,比较两组患者的临床疗效、止疱时间、脱痂时间、疼痛缓解时间、急性神经痛持续时间及后遗神经痛发生情况。结果阿昔洛韦组的总有效率为92.50%,泛昔洛韦组为95.00%,两组总有效率比较,差异无统计学意义(P>0.05)。泛昔洛韦组的止疱时间、脱痂时间、疼痛缓解时间及急性神经痛持续时间均短于阿昔洛韦组,差异有统计学意义(P<0.05)。阿昔洛韦组的后遗神经痛发生率为25.00%,高于泛昔洛韦组的7.50%,差异有统计学意义(P<0.05)。结论阿昔洛韦片与泛昔洛韦片治疗带状疱疹的疗效相当,但泛昔洛韦可有效缩短患者症状改善的时间,且能有效减少后遗神经痛的发生。
Objective To compare the clinical efficacy of acyclovir and famciclovir in the treatment of shingles. Methods Eighty patients with herpes zoster were enrolled in the Yongshu Dermatosis Prevention and Treatment Center from August 2012 to August 2014. The patients were divided into aciclovir group and famciclovir group (n = 40) according to the random number table method. Two groups of patients were given physical therapy, vitamin B1, B12 and topical Yunnanbaiyao routine treatment. The acyclovir group was treated with acyclovir, the famciclovir group was treated with famciclovir tablets, and the clinical efficacy, blister time, scab time, pain relief time, duration of acute neuralgia and post-nociceptivegia were compared between the two groups What happened? Results The total effective rate was 92.50% in acyclovir group and 95.00% in famciclovir group. There was no significant difference between the two groups in total effective rate (P> 0.05). The time of blistering, scabbing, pain relief and duration of acute neuralgia in the famciclovir group were shorter than those in the acyclovir group, with significant difference (P <0.05). The incidence of posthermitatal neuralgia in acyclovir group was 25.00%, which was higher than that in famciclovir group (7.50%), the difference was statistically significant (P <0.05). Conclusions Aciclovir tablets and famciclovir tablets are effective in treating herpes zoster. However, famciclovir can shorten the time of symptom improvement and reduce the incidence of postherpetic neuralgia.