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1949年,Jeghers等发表了全肠息肉病伴口腔粘膜、唇、手指黑色素沉着的报告,此病即普-杰氏综合征(Peutz-Jegher syndrome),亦即皮肤粘膜黑色素斑肠道多发性息肉综合征。Jeghers等当时并指出:结肠多发性息肉易于发生恶性肿瘤是人们熟知的一种倾向,某种程度上对小肠息肉说来也是如此。此结论在实践上暗示要作预防性手术。1957年有相反的意见认为,尽管有好几例组织学上诊断为小肠癌,但患者仍表现了完全良性的临床过程误诊可能是组织学上的误认所致。近年研究的结论认为息肉是一种错构瘤。
In 1949, Jeghers et al. published a report of melanin pigmentation in the mucosa of the entire intestine with polyps in the oral mucosa, lips, and fingers. This disease is known as Peutz-Jegher syndrome, which is a mucocutaneous polyp Syndrome. Jeghers et al. pointed out at the time that it is a well known tendency for multiple colon polyps in the colon to be prone to malignancy, and this is also true of small intestinal polyps. This conclusion implies in practice that preventive surgery is required. In 1957 there was the opposite opinion that although there were several cases of histologically diagnosed small intestine, the patient still showed a completely benign misdiagnosis of the clinical course may be due to histological misidentification. Recent studies have concluded that polyps are a hamartoma.