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目的:建立妇炎消片含量测定标准。方法:采用高效液相色谱法,测定妇炎消片中大黄素、大黄酚的含量。色谱柱:C18(大连伊利特250mm×4.6mm,5μm);流动相:甲醇-0.1%磷酸溶液(85:15);检测波长:254nm;流速:1.0ml/min。结果:妇炎消片大黄素、大黄酚测定样品平均回收率分别为98.89%、99.40%,RSD%分别为0.78、1.09。结论:本含量测定方法结果较好,方法可行,可有效地控制该制剂的质量。
Objective: To establish the standard for the determination of Fu Yan Xiao Tablets. Methods: The contents of emodin and chrysophanol in Fuyanxiao Tablets were determined by high performance liquid chromatography. Column: C18 (Dalian Yilit 250mm×4.6mm, 5μm); mobile phase: methanol-0.1% phosphoric acid solution (85:15); detection wavelength: 254 nm; flow rate: 1.0 ml/min. RESULTS: The average recoveries of emodin and chrysophanol in Fuyanxiao Tablets were 98.89% and 99.40%, respectively, and the RSD% were 0.78 and 1.09, respectively. Conclusion: The determination method of the content is better, the method is feasible, and the quality of the preparation can be effectively controlled.