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本文报导应用环磷酰胺治疗全身性红斑狼疮(SLE)的七年经验。42个住院病人,女性37例,男性5例。发病年龄为15～62岁,15～30岁者占71％,83％病例血中狼疮细胞反应阳性,80％病例有高丙种球蛋白血症,85％病例血沉率升高(超过40毫米/小时),55％病例有贫血(血红蛋白低于10克/100毫升),30％病例血小板减少(血小板少于100,000/立方毫米),25％病例白细胞减少(白细胞少于4,000/立方毫米),77％病例尿检查异常,6例表现为典型的肾病综合征。对31例有显微血尿及/或显著蛋白尿的患者进行了肾活检,结果2例正常,10例为狼疮性肾小球炎,呈轻度局灶性基底膜增厚及增生性改变;19例为狼疮性肾小球肾炎,肾小球严重受累伴有肾小管和间质的改变。
This article reports the seven years of experience with cyclophosphamide in the treatment of systemic lupus erythematosus (SLE). 42 inpatients, 37 females and 5 males. The age of onset was 15-62 years old, accounting for 71% of the patients aged 15-30 years. In 83% of the cases, lupus cells were positive in blood, 80% of cases had hypergammaglobulinemia and 85% of cases had erythrocyte sedimentation rate (over 40 mm / Hour), anemia in 55% of cases (hemoglobin less than 10 g / 100 ml), thrombocytopenia in 30% of cases (platelets less than 100,000 per cubic millimeter), leukopenia in 25% of cases (leukocytes less than 4,000 per cubic millimeter), 77 Urine examination was abnormal in% of cases, and 6 cases showed typical nephrotic syndrome. Thirty - one patients with micro - hematuria and / or significant proteinuria underwent renal biopsy. Results were normal in 2 cases and lupus glomerulonephritis in 10 cases, showing slight focal thickening and proliferative changes of basement membrane. 19 cases of lupus glomerulonephritis, severe involvement of glomerular tubular and interstitial changes.