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目的分析药物不良反应发生的特点和规律,促进临床安全用药。方法对2014年1月—2015年12月北京军区北戴河疗养院326例药物不良反应报告,按年龄、性别、给药途径、引发药物不良反应情况及转归、药物品种分类、心血管系统药物分布、抗感染药物分布、系统损害等进行统计分析。结果326例药物不良反应给药途径以静脉用药最高,占50.00%;新的、严重的药物不良反应82例,占25.15%。326例药物不良反应患者涉及药物15大类,其中心血管系统药物药物不良反应居首位,占30.67%;抗感染药物药物不良反应排第二,占23.62%;药物不良反应系统损害分布情况以肝胆系统损害为主,占54.94%。结论应加强药物不良反应的监测工作,促进临床合理用药。
Objective To analyze the characteristics and rules of adverse drug reactions and to promote clinical safe medication. Methods A retrospective analysis was conducted on 326 cases of adverse drug reactions in Beidaihe Sanatorium from January 2014 to December 2015 in Beijing Military Region. According to the age, sex and route of administration, the adverse reactions and outcomes of drug induced, drug category classification, cardiovascular system drug distribution, Anti-infective drug distribution, system damage and other statistical analysis. Results 326 cases of adverse drug drug delivery route to the highest intravenous medication, accounting for 50.00%; new, serious adverse drug reactions in 82 cases, accounting for 25.15%. 326 cases of adverse drug reactions involving 15 major categories of drugs, including cardiovascular system drug drug adverse reactions in the first place, accounting for 30.67%; anti-infective drug adverse drug reactions ranked second, accounting for 23.62%; adverse drug reaction system damage distribution Liver and gallbladder system damage, accounting for 54.94%. Conclusion The monitoring of adverse drug reactions should be strengthened to promote clinical rational use of drugs.