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生长激素(Growth Hormone,GH)由腺垂体分泌,并通过生长激素受体刺激类胰岛素生长因子(Insui-Like Growth Factors,IGF)的生成发挥其直接效应.生长激素在儿童时期具有促进线性生长的作用,在成人同样具有生理作用.这些作用包括促进氨基酸转运和蛋白质合成,从周围脂肪组织中游离出脂肪酸并减少脂肪的合成.其总体效应为使钙、磷、氮的贮存增加,肌肉体积、力量和运动能力增加.生长激素还具有抗胰岛素作用.并影响碳水化合物的代谢.成人生长激素缺乏综合症(The adult Growth Hormone Deficiency syndrome,GHD)是指患者(儿童或成人)具有一系列临床特征并通过生长激素治疗有效的症候群.随着重组人生长激素替代治疗的临床应用.成人生长激素缺乏正在受到关注,并有望通过替代治疗改善患者的生活质量和寿命.1 成人生长激素缺乏的病因
Growth Hormone (GH) is secreted by the pituitary gland and exerts its direct effect by stimulating the production of Insulin-Like Growth Factors (IGFs) through growth hormone receptors, which have the potential to promote linear growth in childhood They also have physiological effects in adults, including the promotion of amino acid transport and protein synthesis, the liberation of fatty acids from the surrounding adipose tissue and the reduction of fat production, with the overall effect of increasing storage of calcium, phosphorus and nitrogen, muscle mass, Increased strength and exercise capacity. Growth Hormone also has anti-insulin effects and affects carbohydrate metabolism. Adult Growth Hormone Deficiency Syndrome (GHD) refers to patients (children or adults) with a series of clinical features And through the effective treatment of growth hormone syndrome.With the clinical application of recombinant human growth hormone replacement therapy, adult growth hormone deficiency is being concerned about, and is expected to improve patient quality of life and life expectancy through alternative therapies.1 The causes of adult growth hormone deficiency