目的探讨非酒精性脂肪肝(NAFLD)的患病情况与代谢综合征(MS)相关指标变化的关系。方法收集某高校3071例教职工的体检完整资料,分析NAFLD与脂代谢异常、高血压、高血糖、高尿酸水平的关系,并研究不同年龄、性别的NAFLD患病情况。结果 3071例研究对象中,共检出NAFLD患者1022例,患病率为33.28%。随着年龄增长,发病率逐渐升高,男性NAFLD患病率高于女性,差异有统计学意义(P<0.01)。NAFLD组脂代谢异常、高血压、高血糖、高尿酸患病率明显高于非NAFLD组,差异有统计学意义(P<0.01)。NAFLD组体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、谷丙转氨酶(ALT)、尿酸(UA)水平明显高于非NAFLD组,差异有统计学意义(P<0.01)。NAFLD组TG的OR=1.523,BMI的OR=1.325,FBG的OR=1.156,DBP的OR=1.429。由此可见,BMI、FBG、TG、DBP的测试值与NAFLD明显相关。结论 NAFLD的发生不仅与脂代谢障碍有关,而且与年龄、性别以及合并有高脂血症、高血压、高血糖、高尿酸等多种代谢紊乱的全身性疾病密切相关。 Objective To investigate the relationship between the prevalence of non-alcoholic fatty liver disease (NAFLD) and the related indexes of metabolic syndrome (MS). Methods A total of 3071 faculty members in a certain university were collected to analyze the relationship between NAFLD and abnormal lipid metabolism, hypertension, hyperglycemia and hyperuricaemia, and to study the prevalence of NAFLD in different age and gender. Results Among 3071 subjects, 1022 NAFLD patients were detected, the prevalence was 33.28%. With age, the incidence gradually increased, the prevalence of NAFLD in males was higher than that in females, the difference was statistically significant (P <0.01). The prevalence of abnormal lipid metabolism, hypertension, hyperglycemia, and hyperuricemia in NAFLD group was significantly higher than that in non-NAFLD group (P <0.01). Body mass index (BMI), SBP, DBP, TG, TC, HDL-C and LDL-C in NAFLD group were higher than those in NAFLD group LDL-C, FBG, ALT and UA were significantly higher than those in non-NAFLD group (P <0.01). OR of NAFLD group was 1.523 for TG, OR = 1.325 for BMI, OR = 1.156 for FBG and OR = 1.429 for DBP. Thus, BMI, FBG, TG, DBP test values ​​and NAFLD significantly related. Conclusions NAFLD is not only related to dyslipidemia, but also closely related to age, sex and systemic diseases with hyperlipidemia, hypertension, hyperglycemia, hyperuricemia and other metabolic disorders.