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为了解抗结核药物对HBsAg阳性结核性脑膜炎(简称结脑)患者的肝功能有何影响,从而更合理地选用化疗方案。我们收集了资料完整的结脑患者共106例,作一简要分析,现报道如下。 1资料和方法 1.1一般资料 本组106例为1992～1997年间住院患者,其中男71例,女35例,男女比例为2:1;年龄15～70岁,平均38.3岁,106例均符合下列临床诊断标准:①部分有密切的结核接触史;②可有肺部或肺外的结核病灶;③发病缓慢,具结核中毒症状,伴颅内高压、脑膜刺激征及其他神经系统症状和体征;④脑脊液检查符合结核性脑膜炎表现;⑤抗结核治疗有效。入院时均常规检查HBsAg,其中HBsAg阳性者共49例,列为观察组;HBsAg阴性者57例,列为对照组。
To understand the impact of anti-TB drugs on liver function in patients with HBsAg-positive tuberculous meningitis (referred to as tuberculous meningitis), and thus more rational use of chemotherapy. We collected a complete data of 106 patients with tuberculous meningitis, for a brief analysis, are reported below. 1 Materials and Methods 1.1 General Information The group of 106 patients were hospitalized from 1992 to 1997, including 71 males and 35 females, male to female ratio of 2: 1; aged 15 to 70 years, mean 38.3 years, 106 cases were in line with the following Clinical diagnostic criteria: ① part of the history of close contact with tuberculosis; ② may have pulmonary or extrapulmonary tuberculosis; ③ slow onset, with symptoms of tuberculosis, with intracranial hypertension, meningeal irritation and other neurological symptoms and signs; ④ cerebrospinal fluid examination consistent with tuberculous meningitis performance; ⑤ anti-TB treatment effective. During admission, routine examination of HBsAg, including HBsAg-positive in a total of 49 cases were included in the observation group; HBsAg-negative in 57 cases, as a control group.