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目的探讨应用维生素E联合达英-35治疗多囊卵巢综合征(PCOS)患者的临床应用价值。方法收集2015年5-7月于广东省妇幼保健院门诊就诊的PCOS不孕症患者113例,随机分为试验组(n=56)和对照组(n=57)。对照组单用达英-35,于月经周期第5天开始口服,每晚1片,连续21 d;试验组在对照组的基础上加用维生素E,0.1g/次,3次/d。治疗3个月后,比较两组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、和雄烯二酮(And)及LH/FSH的变化,并统计停药3个月内的自然周期累积妊娠率。结果试验组和对照组治疗后LH、T、And及LH/FSH比值较治疗前均明显下降(P<0.05),FSH水平与治疗前差异无统计学意义(P>0.05)。停药后3个月内,试验组自然周期累积妊娠率为17.8%,高于对照组的12.3%,但差异无统计学意义(P>0.05)。结论维生素E联合达英-35及单用达英-35治疗PCOS,均可明显改善高雄状态,前者可能更有利于自然妊娠。
Objective To investigate the clinical value of vitamin E combined with daun-35 in the treatment of patients with polycystic ovary syndrome (PCOS). Methods A total of 113 infertile women with PCOS were enrolled in the MCH clinic in Guangdong Province from May to July in 2015. The patients were randomly divided into experimental group (n = 56) and control group (n = 57). The control group was orally administered with Ying-35. Oral administration was started on the fifth day of the menstrual cycle, one tablet per night for 21 consecutive days. The experimental group was supplemented with vitamin E (0.1g / time, 3 times / d) on the basis of the control group. After treatment for 3 months, the changes of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), and And and LH / FSH were compared before and after treatment The cumulative natural pregnancy rate within months. Results The ratio of LH, T, And and LH / FSH in experimental group and control group decreased significantly (P <0.05) before treatment, but there was no significant difference in FSH level between before and after treatment (P> 0.05). Within 3 months after discontinuation, the cumulative pregnancy rate in the natural cycle of the experimental group was 17.8%, which was higher than that of the control group (12.3%), but the difference was not statistically significant (P> 0.05). Conclusions Vitamin E combined with da-Ying-35 and da-Ying-35 alone can significantly improve the status of Kaohsiung, the former may be more conducive to natural pregnancy.