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A new asymmetric bidentate copper(Ⅱ) complex,CuL 2(HL=2-((E)-(4-bromophenylimino)methyl)-6-bromo-4-chlorophenol),has been synthesized and characterized by elemental analyses and single-crystal X-ray diffraction.The complex crystallizes in the monoclinic space group P2 1 /c with a=11.218(3),b=9.355(3),c=13.449(4),β=108.722(4)°,V=1336.8(6)3,Z=2,Dc=2.008 g/cm 3,μ(MoKα)=7.024 mm-1,F(000)=806,S=0.999,the final R=0.0342 and wR=0.0641for2611observed reflections (I>2σ(I)).The central copper(Ⅱ) is four-coordinate and bonds to two nitrogen and two oxygen atoms from two Schiff base ligands.The complex is linked into a two-dimensional supramolecular structure by weak intermolecular interactions.In addition,DNA-binding properties of the metal complex were investigated using spectrometric titrations and viscosity measurements.The results show that the complex binds with calf-thymus DNA(CT-DNA),presumably via a partial intercalative mode.The intrinsic binding constant of the Cu(Ⅱ) complex with DNA is 7.335×10 3 M-1.
A new asymmetric bidentate copper (II) complex, CuL 2 (HL = 2 - ((E) - (4-bromophenylimino) methyl) -6-bromo-4-chlorophenol, has been synthesized and characterized by elemental analyzes and single- crystal X-ray diffraction.The complex crystallizes in the monoclinic space group P2 1 / c with a = 11.218 (3), b = 9.355 (3), c = 13.449 (4), β = 108.722 (4) °, V = F (000) = 806, S = 0.999, the final R = 0.0342, and wR = 0.0641for2611observed reflections (1336.8) for Z = 2 and Dc = 2.008 g / (I> 2σ (I)). The central copper (Ⅱ) is four-coordinate and bonds to two nitrogen and two oxygen atoms from two Schiff base ligands. The complex is linked into a two-dimensional supramolecular structure by weak intermolecular interactions. In addition, DNA-binding properties of the metal complex were investigated using spectrometric titrations and viscosity measurements. The results show that the complex binds with calf-thymus DNA (CT-DNA), presumably via a partial intercalative mode. Intrinsic binding constant of the Cu (Ⅱ) complex with DNA is 7.335 × 10 3 M-1.