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目的观察奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血的疗效。方法 86例肝硬化食管胃底静脉曲张破裂出血患者,随机分为三组,分别应用奥曲肽(1组,30例)、垂体后叶素(2组,28例)、奥曲肽+垂体后叶素(3组,28例)进行治疗。结果 1组治疗显效率73.3%,总有效率93.3%;2组治疗显效率39.3%,总有效率67.9%;3组治疗显效率75.0%,总有效率92.9%;其中1组、3组明显高于2组(P<0.05),但1组与3组比较无差别。结论奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血安全有效,联合应用垂体后叶素并不能提高疗效。
Objective To observe the efficacy of octreotide in the treatment of patients with esophageal and gastric variceal bleeding due to cirrhosis. Methods Eighty - six patients with esophageal and gastric variceal bleeding were randomly divided into three groups: octreotide (group 1, n = 30), vasopressin (n = 28), octreotide and vasopressin 3 groups, 28 cases) for treatment. Results The effective rate of treatment in group 1 was 73.3%, the total effective rate was 93.3%. In group 2, the effective rate was 39.3% and the total effective rate was 67.9%. The effective rate of three groups was 75.0% and the total effective rate was 92.9% Higher than the two groups (P <0.05), but there was no difference between the first group and the third group. Conclusion Octreotide is safe and effective in the treatment of patients with cirrhosis and esophageal variceal bleeding. Combined application of vasopressin does not improve the curative effect.