碱性成纤维细胞生长因子与肿瘤相关物质群的检测在急性白血病中的临床应用

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目的探讨急性白血病(AL)患者血清碱性成纤维细胞生长因子(bFGF)及恶性肿瘤相关物质群(TSGF)的水平及其临床意义。方法应用酶联免疫法(ELISA)及化学显色法分别对47例AL初治患者、8例复发患者化疗前及化疗后11例完全缓解(CR)患者、13例难治(NR)患者血清bFGF及TSGF的水平分别进行检测,并与正常对照组比较。结果AL初治组及复发组血清bFGF水平均明显高于正常人对照组水平,差异有非常显著性意义(t=6.71,6.18,P<0.001);AL初治组及复发组血清TSGF水平均明显高于正常人对照组水平,差异非常显著(t=6.847,5.009,P<0.001);CR患者血清bFGF水平及TSGF水平均明显下降,与正常对照组相比较,差异均无显著性意义(t=1.11,1.482,P>0.05);急性淋巴细胞白血病(ALL)NR组化疗前血清bFGF水平明显高于CR组化疗前的水平,差异具有显著性意义(t=2.43,P<0.05),而急性髓细胞性白血病(AML)NR组与CR组化疗前血清bFGF水平无显著性差异(t=0.76,P>0.05);ALL与AML患者NR组化疗前血清TSGF水平均高于CR组化疗前的水平,且差异均具有统计学意义(t=3.29,2.13,P<0.01,0.05);血清bFGF水平与TSGF水平呈正相关(r=0.5263,P<0.01)。结论联合检测血清bFGF及TSGF水平对了解AL的发生、发展及疗效观察有一定临床价值。 Objective To investigate the serum levels of basic fibroblast growth factor (bFGF) and malignant tumor related substances (TSGF) in patients with acute leukemia (AL) and its clinical significance. Methods Serum levels of 11 patients with complete remission (CR) and 13 patients with refractory (NR) before chemotherapy and after chemotherapy were detected in 47 patients with AL-naive and 8 patients relapsed by enzyme-linked immunosorbent assay (ELISA) bFGF and TSGF levels were detected and compared with the normal control group. Results The levels of serum bFGF in AL group and relapse group were significantly higher than those in control group (t = 6.71,6.18, P <0.001). The levels of serum TSGF in AL group and relapse group were significantly higher than those in control group (T = 6.847, 5.009, P <0.001). The levels of serum bFGF and TSGF in CR patients were significantly lower than those in normal controls (P <0.001), but there was no significant difference between the two groups t = 1.11,1.482, P> 0.05). The level of serum bFGF in patients with acute lymphoblastic leukemia (ALL) before chemotherapy was significantly higher than that in patients with CR before chemotherapy (t = 2.43, P < The levels of serum bFGF in patients with acute myelogenous leukemia (AML) and CR before chemotherapy had no significant difference (t = 0.76, P> 0.05). The levels of serum TSGF in patients with ALL and AML before NRT were higher than those in patients with CR (T = 3.29,2.13, P <0.01, 0.05). Serum bFGF level was positively correlated with TSGF level (r = 0.5263, P <0.01). Conclusions Combined detection of serum bFGF and TSGF level has certain clinical value in understanding the occurrence, development and therapeutic effect of AL.
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