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目的观察万托林联合布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)疗效。方法选择我院在2012年1月~2013年6月收治的60例AECOPD患者,按照就诊时间顺序随机分为四组,每组15例,A组患者给予鼻导管低流量吸氧、营养支持、纠正酸碱失衡、止咳化痰药物依照病原学和病情而定。B组在A组上加用5ml生理盐水+2.5ml万托林雾化吸入;C组在A组上加用5ml生理盐水+2ml布地奈德雾化吸入;D组在A组上加用3ml生理盐水+2ml布地奈德+2.5ml万托林雾化吸入;各组治疗疗程均为7~10d,每次15~20min,3~4次/d。结果 A组患者治疗后总有效率为60.00%;B组患者治疗后总有效率为73.33%;C组患者治疗后总有效率为80.00%;D组患者治疗后总有效率为93.33%。结论单用布地奈德或万托林来对AECOPD进行雾化吸入,治疗效果不显著,而将两种药物联合使用,则临床疗效更为显著,无不良反应和并发症发生,值得在临床上大量推广应用。
Objective To observe the efficacy of intravenous injection of etoposide and budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty patients with AECOPD who were treated in our hospital from January 2012 to June 2013 were randomly divided into four groups (n = 15 in each group) according to the time sequence of treatment. Patients in group A received nasal catheter low-flow oxygenation and nutrition support, Correct acid-base imbalance, cough and phlegm drugs in accordance with the etiology and disease may be. Group B in group A plus 5ml saline + 2.5ml Wanlin inhalation; Group C in group A plus 5ml saline + 2ml budesonide inhalation; Group D in group A plus 3ml Saline + 2ml budesonide + 2.5ml wanlin inhalation; each course of treatment were 7 ~ 10d, each 15 ~ 20min, 3 ~ 4 times / d. Results The total effective rate in group A was 60.00%. The total effective rate in group B was 73.33%. The total effective rate in group C was 80.00%. The total effective rate in group D was 93.33%. Conclusions Anesthesin alone or vanadolin alone can inhale AECOPD, but the effect is not obvious. Combined use of the two drugs results in more obvious clinical effect and no adverse reactions and complications, which is worth to be clinically A large number of promotion and application.