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对月经期肌无力加重的36倒重症肌无力(MG)病人作了月经前后女性激素的检测,以探讨女性激素与重症肌无力的关系。结果表明;月经前后的促卵泡生成素(FSH)、催乳素(PRL)、雌二醇(E2)、孕酮(P)的均值明显高于正常对照组。月经前的促黄体生成素(LH)低于正常组,但无统计学意义(P>0.05),说明LH对MG无影响。FSH影响较小。PRL、E2和P对MG有影响(均为P<0.01)。MG病人血清PRL值应在正常范围,这就提示MG病人月经期病情加重可能是PRL、E2和P的增高所致,说明血清PRL、E2和P的增高与肌无力加重有关。
Menstrual myasthenia gravis aggravated 36 patients with myasthenia gravis (MG) made before and after menstruation female hormone test to explore the relationship between female hormone and myasthenia gravis. The results showed that the mean values of FSH, PRL, E2 and progesterone before and after menstruation were significantly higher than those of the normal control group. Pre-menstrual luteinizing hormone (LH) was lower than the normal group, but not statistically significant (P> 0.05), indicating that LH had no effect on MG. FSH less affected. PRL, E2 and P had effects on MG (all P <0.01). MG patients with serum PRL value should be within the normal range, which suggests that MG patients with menstruation aggravate may be caused by PRL, E2 and P increased, indicating that serum PRL, E2 and P increased with the aggravation of myasthenia gravis.