Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims. Objective: To investigate the analgesic activity of methanolic extract of Amaranthus viridis (A. Viridis), Amaranthus caudatus (A.caudatus) and Amaranthus spinosus (A.spinosus). Methods: In this study, the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg / kg were investigated by acetic acid-induced writhings test, hot plate test and tail immersion test for mice. Results: It was found that all the three plants showed significant pain management effect (P <0.01) at a dose of 400 mg / kg, but showed a less significant effect at a dose of 20 mg / kg in the entire tests used for evaluation of analgesic activities (P <0.05) .Conclusions: Methanol extracts of A. viridis, A. caudatus and A. spinosus show potent analgesic activities, and this study provides the scientific proof for their traditional claims.