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目的分析探讨在急性脑梗死治疗中两种降颅压药的治疗效果与安全性。方法 113例急性脑梗死患者,采用数字随机分组分为A组(58例)与B组(55例)。A组在常规治疗的基础上行甘油果糖治疗,B组在常规治疗的基础上行甘露醇治疗,比较两组患者治疗的效果以及神经功能缺损评分情况和对肾功能的影响。结果两组治疗效果比较差异无统计学意义(P>0.05);两组治疗后的神经功能缺损评分均比治疗前有显著改善(P<0.01),但组间比较差异无统计学意义(P>0.05);治疗后A组肾功能异常患者1例(1.7%),B组肾功能异常7例(12.7%),两组比较差异有统计学意义(P<0.05)。结论在在急性脑梗死治疗中,甘油果糖与甘露醇的治疗效果均较好,两种药物治疗效果相当,而甘油果糖对肾功能的损害明显小于甘露醇治疗,安全性更好。
Objective To analyze the therapeutic effect and safety of two intracranial agents in the treatment of acute cerebral infarction. Methods A total of 113 patients with acute cerebral infarction were randomly divided into group A (58 cases) and group B (55 cases). Group A was treated with glycerol fructose on the basis of routine treatment. Group B received mannitol treatment on the basis of routine treatment. The therapeutic effect of two groups of patients and the score of neurological deficit and the effect on renal function were compared. Results There was no significant difference in therapeutic effect between the two groups (P> 0.05). The scores of neurological deficit after treatment in both groups were significantly improved (P <0.01), but there was no significant difference between the two groups (P > 0.05). After treatment, 1 patient (1.7%) had renal dysfunction in group A and 7 patients (12.7%) had abnormal renal function in group B, the difference was statistically significant (P <0.05). Conclusion In the treatment of acute cerebral infarction, glycerol fructose and mannitol treatment are good, the two drugs are quite effective, and glycerol fructose on renal function was significantly less than the mannitol treatment, better security.