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采用免疫组化染色方法，对５２例贲门癌患者的癌组织进行了Ｐ１６及ｎｍ２３基因染色检测。结果贲门癌组织Ｐ１６基因染色阳性率为６９％，癌旁组织为９２％，两者差异显著（Ｐ＜０．０１）；分化较好的癌组织染色阳性率为７５％，分化较差者为２５％，两者差异显著（Ｐ＜０．０１）。贲门癌组织ｎｍ２３基因染色阳性率为７１％，癌旁组织为９８％，两者差异显著（Ｐ＜０．０１）：分化较好的癌组织染色阳性率为７６％，分化较差者为２４％，两者差异显著（Ｐ＜０．０１）。Ｐ１６及ｎｍ２３基因表达与肿瘤分化程度显著相关，与年龄、性别、家族史、淋巴结转移等无关。提示Ｐ１６及ｎｍ２３基因低表达在贲门癌的发生中可能起重要作用。
Immunohistochemical staining was used to detect P16 and nm23 in 52 cases of cardiac cancer. RESULTS: The positive rate of P16 gene staining in cardiac cancer tissues was 69%, and paraneoplastic tissues were 92%. There was significant difference between the two groups (P<0.01). The positive staining rate of cancer tissues with better differentiation was 75%. 25%, the difference between the two significant (P <0.01). The positive rate of nm23 gene staining was 71% in cancer tissues and 98% in adjacent tissues (P<0.01). The positive staining rate of well-differentiated cancer tissues was 76%, and poor differentiation was 24%. %, the difference between the two significant (P <0.01). The expression of P16 and nm23 genes was significantly associated with the degree of tumor differentiation, and was not related to age, gender, family history, lymph node metastasis, or the like. This suggests that the low expression of P16 and nm23 genes may play an important role in the occurrence of cardiac cancer.