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人类锰中毒的特征表现是椎体外系障碍。啮齿类动物对锰虽具有相当的耐受力,但暴露于锰的大鼠和小鼠仍可出现行为功能障碍。近年来,临床上试用PAS-Na治疗锰中毒患者,取得较好的效好的效果。本研究以MnCl_2·4H_2O对大鼠亚慢性染毒后,给予PAS-Na,观察对锰染毒大鼠的
Characterization of human manganese poisoning is an extra-vertebral disorder. Although rodents are fairly tolerant of manganese, behavioral dysfunction can still occur in manganese-exposed rats and mice. In recent years, clinical trials PAS-Na treatment of manganese poisoning patients, and achieved good effect. In this study, rats were sub-chronically exposed to MnCl 2 · 4H 2 O, PAS-Na was administered to observe the effects of manganese on rats