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目的就丹参注射液抗肝炎肝纤维化效果的量效进行研究。方法选择2008年6月～2013年6月我院收治的慢性乙肝患者142例,将其分为中剂量组(35例)、低剂量组(36例)、高剂量组(35例)、对照组(36例)。对照组常规治疗,低剂量组在此基础上注射10ml丹参注射液,中剂量组注射20ml丹参注射液,高剂量组注射30ml丹参注射液。结果对照组在降低肝纤四项指标方面都劣于高、中、低剂量组,低剂量组劣于中剂量组,中剂量组劣于高剂量组,具有较为明显的差异,有统计学意义(P<0.05)。结论高剂量的丹参注射液对于抗肝炎肝纤维化效果较佳,值得深入推广。
Objective To study the effect of Danshen injection on the anti-hepatic fibrosis effect. Methods 142 patients with chronic hepatitis B admitted to our hospital from June 2008 to June 2013 were divided into medium dose group (35 cases), low dose group (36 cases), high dose group (35 cases), and control group Group (36 cases). Control group, conventional treatment, low-dose group on the basis of injection of 10ml Danshen injection, the middle dose group injection of 20ml Danshen injection, high-dose group injection of 30ml Salvia injection. Results The control group was inferior to the high, middle and low dose groups in reducing the four indexes of liver fibrosis. The low dose group was inferior to the middle dose group, the middle dose group was inferior to the high dose group, with obvious difference (P <0.05). Conclusion High dose of Salvia miltiorrhiza injection has better effect on anti-liver fibrosis, which is worth further promotion.