危重患儿可发生胰腺损害,病理学检查显示胰腺可呈出血、坏死表现,这与其危重状态相关。目前临床研究及动物实验模型研究证实,危重患儿胰腺损害的发病机制是复杂的、多因素参与的病理生理过程,可能主要涉及细菌移位和内毒素血症、内脏低灌注和缺血再灌注、血管损伤和血栓形成以及代谢抑制等。 Pancreatic damage can occur in critically ill children, pathological examination showed that the pancreas showed bleeding, necrosis, which is associated with its critical state. The current clinical studies and experimental animal models confirmed that the pathogenesis of pancreatic damage in critically ill children is a complex and multifactorial pathophysiological process that may mainly involve bacterial translocation and endotoxemia, visceral hypoperfusion and ischemia-reperfusion , Vascular injury and thrombosis, and metabolic inhibition.