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目的 :利用单相动作电位 ( MAP)技术研究在整体条件下四氢巴马汀对家犬心室肌 MAP时程的使用依赖性。方法 :同时记录家犬 ( 12只 )右室心尖部的 MAP和体表标准 II导联心电图 ,比较给药前后和在窦性心律以及 2 3 0、2 60、2 90、3 2 0次 /min起搏频率下心室肌有效不应期 ( ERP)、MAP复极 5 0 % ( MAPD50 )和复极 90 %( MAPD90 )的变化。结果 :给药 3 0 min( 2 0 m g/kg)后 ,在同一起搏频率下 ,ERP、MAPD50 、和 MAPD90 均明显延长 ,与给药前相比差异有极显著性意义 ( P <0 .0 1) ;随起搏频率增加 ,ERP、MAPD50 和 MAPD90 逐渐缩短 ,但比较给药后不同起搏频率与窦性心律时的 ERP、MAPD50 和 MAPD90 变化率以及 ERP/MAPD90 比值的变化 ,则差异无显著性意义 ( P >0 .0 5 )。结论 :在整体条件下 ,四氢巴马汀无逆向使用依赖性。
OBJECTIVE: To investigate the dependence of tetrahydropalmatine on ventricular MAP time-history in domestic dogs using monophasic action potential (MAP) technique. Methods: The electrocardiogram of MAP and body surface standard II lead of right atrium of 12 domestic dogs (12 dogs) were recorded at the same time. Before and after the administration, in the sinus rhythm and at 230,260,290,320 times / min pacing rate of ventricular effective refractory period (ERP), MAP 50% MAPP50 and 90% (MAPD90) of repolarization. Results: After administration of 30 min (20 mg / kg), the ERP, MAPD50 and MAPD90 were significantly prolonged at the same pacing frequency, which was significantly different from that before administration (P <0. The ERP, MAPD50 and MAPD90 gradually shortened with the increase of pacing frequency. However, comparing the changes of ERP, MAPD50 and MAPD90 and the ratio of ERP / MAPD90 at different pacing rates and sinus rhythm after administration, the differences No significant (P> 0.05). CONCLUSIONS: Tetrahydropalmatine has no adverse dependence on overall conditions.