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目的探讨成分输血在产科大出血并发急性弥散性血管内凝血中的临床应用效果。方法选取该院妇产科紧急救治的大出血并发急性弥散性血管内凝血患者77例,根据输血方式不同分为两组,采用全血输血的33例患者设为对照组;采取成分输血的34例患者设为观察组。比较两组患者凝血功能4项指标、治疗效果及不良反应的发生情况。结果 1观察组患者的纤维蛋白原(FIB)为(7.66±1.43)g/L、凝血酶时间(TT)为(17.27±5.12)s明显高于对照组FIB(3.53±1.84)g/L、TT(15.71±5.63)s,差异有统计学意义(P<0.05);2观察组患者的凝血酶原时间(PT)为(12.84±2.09)s、活化部分凝血酶时间(APTT)为(23.64±3.38)s明显低于对照组的PT(16.02±2.14)s、APTT(26.43±3.72)s,差异有统计学意义(均P<0.05);3观察组患者的治疗有效率为94.12%明显高于对照组的69.70%,差异有统计学意义(均P<0.05);4观察组患者的不良反应发生率为8.82%明显低于对照组的30.30%,差异有统计学意义(均P<0.05)。结论成分输血在抢救产科大出血并发急性弥散性血管内凝血患者能够有效提高凝血功能、降低死亡率及减少不良反应的发生。
Objective To explore the clinical application of component blood transfusion in obstetric hemorrhage complicated with acute disseminated intravascular coagulation. Methods A total of 77 patients with acute hemorrhage complicated with acute disseminated intravascular coagulation were randomly divided into two groups according to different transfusion methods. Thirty-three patients with whole blood transfusion were selected as control group. 34 patients Patients were set as observation group. Four indicators of coagulation function were compared between two groups, and the treatment effect and the incidence of adverse reactions were compared. Results The fibrinogen (FIB) of the observation group was (7.66 ± 1.43) g / L and the thrombin time (TT) was (17.27 ± 5.12) s, significantly higher than that of the control group (3.53 ± 1.84 g / L) TT (15.71 ± 5.63) s, the difference was statistically significant (P <0.05); 2 The prothrombin time (PT) in the observation group was (12.84 ± 2.09) s and the activated partial thromboplastin time (APTT) ± 3.38) s was significantly lower than the control group (16.02 ± 2.14) s, APTT (26.43 ± 3.72) s, the difference was statistically significant (all P <0.05); 3 observation group, the treatment effective rate was 94.12% (P <0.05). The incidence of adverse reactions in the observation group was 8.82%, which was significantly lower than that in the control group (30.30%), the difference was statistically significant (P < 0.05). Conclusion The transfusion of blood can effectively improve the blood coagulation function, reduce the mortality rate and reduce the incidence of adverse reactions in rescue of patients with obstructive haemorrhage complicated with acute disseminated intravascular coagulation.