论文部分内容阅读
目的 比较心肌肌钙蛋白I(CTnI)与几种常用的急性心肌梗死 (AMI)诊断标记物的临床应用价值。方法 对36例AMI和70例非心肌梗死患者同时检测血清CTnI、肌酸激酶 (CK)、肌酸激酶同功酶 (CK -MB)、乳酸脱氢酶 (LDH)、天冬氨酸转氨酶 (AST)和α -羟丁酸脱氢酶 (α -HBD)等6项指标 ,并进行2组间比较 ,分别对AMI和非心肌梗死组各指标间的差异作对比分析。结果 CTnI诊断AMI的敏感性 (91.7 % )高于CK(75.0 % )、CK -MB(63.9 % )、AST(66.3 % )、LDH(75.0% )、α -HBD(69.4 % ) ,P<0.05～0.01 ;CTnI诊断AMI的特异性(95.7 %)与CK -MB(92.6 % )相近 (P>0.05) ,高于CK(84.3 % )、AST(81.4 % )、LDH(72.9% )及α -HBD(80.0% ) ,P<0.05～0.01。结论CTnI对AMI的诊断具有较高的敏感性和特异性 ,作为一种心肌损伤的特异标记物 ,具有较好的临床应用价值
Objective To compare the diagnostic value of cardiac troponin I (CTnI) with several commonly used diagnostic markers of acute myocardial infarction (AMI). Methods Serum CTnI, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase AST) and α - hydroxybutyrate dehydrogenase (α - HBD) were measured and compared between the two groups. The differences between the indexes of AMI and non - myocardial infarction group were analyzed respectively. Results The sensitivity of CTnI in diagnosing AMI was higher than CK (75.0%), CK-MB (66.3%), LDH (75.0%) and α-HBD 0.01). The specificity of CTnI in the diagnosis of AMI was 95.7%, which was similar to that of CK - MB (92.6%) (P> 0.05) HBD (80.0%), P <0.05 ~ 0.01. Conclusion CTnI has a high sensitivity and specificity for the diagnosis of AMI. As a specific marker of myocardial injury, CTnI has a good clinical value