OBJECTIVE:To evaluate the clinical efficacy of Chinese medicine formula HB01 on exudative age-related macular degeneration (AMD) patients who received HB01 for 6 months by analyzing relative indexes.METHODS:From July 2006 to August 2015,139 eligible exudative AMD patients (183 eyes) were enrolled into this study and received aqueous extract from herbs of HB01 by oral twice a day (100 mL for once) for 6 months.The best corrected visual acuity,center macular thickness (CMT),hemorrhage area,fluorescein leakage area as the main outcomes were estimated and compared before and after treatment.RESULTS:After 3 and 6 months of treatment,visual acuity obtained a greater improvement (P ＜ 0.01).After 1,3 and 6 months of treatment,CMT obviously decreased (P ＜ 0.05).After 3 and 6 months of treatment,the hemorrhage area and fluorescein leakage area also significantly narrowed (P ＜ 0.01).During treatment,no significant adverse events relating to HB01 treatment were elucidated.CONCLUSION:On the basis of these results,HB01 could improve visual acuity,and reduce hemorrhage and fluorescein leakage of patients with exudative AMD,which may be an effective altative and supportive treatment for exudative AMD.