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目的观察参麦注射液治疗多西他赛化疗方案所致骨髓毒性的疗效。方法将54例应用多西他赛化疗方案的乳腺癌患者随机分为两组,对照组(25例)采用标准方案化疗,治疗组(29例)在化疗前1d开始加用参麦注射液50ml静脉滴注,每日1次,连用14d为1个疗程。化疗前、化疗后当日、化疗后第7、14天检测WBC、Hb和Plt水平的变化,2个化疗周期结束后比较两组化疗完成率。结果两组患者化疗后第7天和第14天WBC、Hb和Plt水平均较本组化疗后当日上升(P<0.05),且治疗组化疗后第14天WBC、Hb和Plt水平高于对照组(P<0.05)。治疗组的化疗完成率高于对照组(86.2%vs.72.0%)(P<0.05)。结论参麦注射液能减轻多西他赛化疗方案所致的骨髓毒性。
Objective To observe the therapeutic effect of Shenmai injection on myelotoxicity induced by docetaxel chemotherapy. Methods Fifty-four breast cancer patients receiving chemotherapy with docetaxel were randomly divided into two groups. The control group (n = 25) received standard chemotherapy and the treatment group (n = 29) received Shenmai injection 50ml Intravenous infusion, 1 day, once every 14d for a course of treatment. The changes of WBC, Hb and Plt levels were detected before chemotherapy, on the day after chemotherapy, on the 7th and 14th days after chemotherapy, and the completion rates of two groups were compared after the two chemotherapy cycles. Results The levels of WBC, Hb and Plt on the 7th and 14th day after chemotherapy in both groups were significantly higher than those on the day after chemotherapy (P <0.05), and the levels of WBC, Hb and Plt in the treatment group were significantly higher than those on the 14th day after chemotherapy Group (P <0.05). The completion rate of chemotherapy in the treatment group was higher than that in the control group (86.2% vs.72.0%) (P <0.05). Conclusion Shenmai injection can reduce the myelotoxicity induced by docetaxel chemotherapy.