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目的探讨采用高分辨率显微CT(Micro-CT)研究大鼠周围神经微血管三维构筑的可行性,比较两种不同的造影剂对成像效果的影响。方法 SD大鼠40只,随机分为2组,分别灌注明胶-氧化铅和Microfil,取大鼠两侧坐骨神经行Micro-CT扫描,同时设定电压30kVP、功率40W作为成像时的最佳能量参数。将扫描得到的断层图像转变为Dicom格式输出至个人电脑,利用Mimics 10.0软件对其进行三维重建。结果将灌注不同造影剂后得到的标本图片分别从大体和三维两个方面进行对照,发现明胶-氧化铅的造影效果明显优于Microfil;Micro-CT在扫描重建时呈现出低耗时、低变化以及高清晰度的特点。结论 Microfil在灌注微血管造影时存在着灌注压力要求高、成像质量差等缺点,而传统的明胶-氧化铅在微血管造影上仍有其独到的优越性;Micro-CT不失为一种研究大鼠周围神经微血管三维构筑的好方法。
Objective To investigate the feasibility of using high-resolution microscopic CT (Micro-CT) to study the three-dimensional construction of peripheral nerve microvessels in rats and compare the effects of two different contrast agents on the imaging results. Methods Forty Sprague-Dawley rats were randomly divided into two groups. Gelatin-lead oxide and Microfil were respectively perfused. Micro scintigraphy scan was performed on both sides of the sciatic nerve in rats. Voltage of 30kVP and power of 40W were set as the best energy parameters . The scanned tomographic images were converted to Dicom format and output to a PC for 3D reconstruction using Mimics 10.0 software. Results Compared with Microfil, the contrast effect of gelatin-lead oxide was better than that of Microfil. Micro-CT showed low-consumption and low-change during scanning reconstruction And high-definition features. Conclusion Microfil perfusion microvascular angiography there is a high perfusion pressure, poor imaging quality shortcomings, while the traditional gelatin - lead oxide in microangiography still has its unique advantages; Micro-CT is a study of rat peripheral nerve A good way to build micro-capillaries three-dimensionally.