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血浆极低密度脂蛋白(VLDL)的代谢有三条旁路~(1)。一条是表面旁路,即VLDL在分解代谢过程中其表面组分参入到HDL分子内;另一条为核心旁路即VLDL经IDL转变成LDL的途径;第三条旁路为残基旁路,即VDL的某些组分IDL(中间密度脂蛋白)被肝脏摄取的过程。用同位素标记法在动物体内证实~(2’3’4),血浆VLDL分解代谢过程中,VLDL组分内的胆固醇酯的含量中有71～75％经第三条旁路被肝摄取,有2～5％的含量沿核心旁路代谢存于IDL及LDL分子内。说明正常动物体内VLDL-CHE转变成LDL-CHE是一条次要的途径,而第三条途径是VLDL-CHE分解代谢的主要途径。
Plasma very low density lipoprotein (VLDL) metabolism of three bypass ~ (1). One is the surface by-pass, which VLDL in the process of catabolism its surface components into the HDL molecules; the other is the core bypass that VLDL IDL into LDL pathway; the third bypass is the residue bypasses, The process by which certain components of the VDL, IDL (mid-density lipoprotein), are taken up by the liver. In animals, ~ (2’3’4) is confirmed by isotope labeling. In the process of plasma VLDL catabolism, 71-75% of the cholesterol ester content in the VLDL component is taken up by the liver via the third bypass. There are Levels of 2 to 5% are metabolized in the IDL and LDL molecules along the core bypass. This shows that the conversion of VLDL-CHE to LDL-CHE is a secondary pathway in normal animals, and the third pathway is the main pathway of VLDL-CHE catabolism.