目的　了解曼氏血吸虫吡喹酮抗性株对终宿主致病作用的强弱。方法　采用浸尾法以2 0 0尾蚴 /鼠逐只感染远交系 CD1 鼠 ,感染 5 7d后采集鼠粪便计数虫卵 ;78d后剖杀鼠收集成虫计数并摘取肝脏和肠做组织虫卵计数 ;95 d后取肝组织 ,切片、染色测量虫卵肉芽肿面积和周长。比较抗性株与敏感株对终宿主的易感性、产卵量和肝虫卵肉芽肿面积。结果　抗性株和敏感株感染鼠成虫回收数为 2 2 .5条 /鼠和 2 1.8条 /鼠 ;抗性株感染鼠粪便虫卵数为 6 8.6只 / 10 0 mg,敏感株为 31.7只 / 10 0 m g,两者间差异有非常显著性 ;感染第 78天 ,抗性株组织虫卵数为 836 4只 /对成虫 ,敏感株为 4 6 6 5只 /对成虫 ,两者间差异有非常显著性 ;敏感株产于肝和肠组织虫卵数为 15 4 0只 /对成虫和 312 4只 /对成虫 ,抗性株分别为 4 2 97只 /对成虫和 3887只 /对成虫 ;抗性株和敏感株感染鼠肝虫卵肉芽肿面积分别为 392 2 36 μm2和 5 2 32 6 3μm2 ,周长分别为 2 385 μm和 2 882 μm,两者间差异均无显著性。结论　抗性株在粪便与组织中产卵量均高于敏感株 ,故抗性株对终宿主的致病作用强于敏感株。 Objective To understand the effect of praziquantel-resistant strains of Schistosoma mansoni on the pathogenicity of the final host. Methods Inoculation method was used to infect coccidiosis mice with murine peritoneal dialysis virus (CD18) inoculated with coccidiosis peritonei and mice were collected for stool counts after 57 days. After 78 days, the mice were sacrificed to collect adult worms and the liver and intestine were harvested Counting; After 95 days, the liver tissues were taken, sliced ​​and stained to measure the area and perimeter of the egg granuloma. To compare the susceptibility of the resistant and susceptible strains to the final host, the fecundity and the area of ​​hepatic worm granuloma. Results The number of recovered adult worms infected with resistant and susceptible strains was 22.5 and 2 1.8 per mouse, respectively. The number of eggs infected by the resistant strains was 6 8.6 per 100 mg and the susceptible strain was 31.7 / 10 0 mg, the difference between the two groups was significant. On the 78th day after infection, the number of eggs in the resistant strain was 836 4 / adult and the sensitive strain was 4666 / adult, the difference between the two The number of eggs produced by the sensitive strains in the liver and intestine was 15 40 per adult and 312 4 adults per adult and the resistant strains were 4 2 97 per adult and 3887 per adult respectively . The area of ​​eggs granuloma infected by resistant and susceptible strains was 392 2 36 μm 2 and 5232 6 3 μm 2, respectively, with a circumference of 2 385 μm and 2 882 μm, respectively. There was no significant difference between the two groups. Conclusion The resistance of the resistant strains to fecundity and tissue were higher than those of the sensitive strains, so the resistant strains were more virulent than the susceptible strains.