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呼吸系统疾病如感冒,支气管炎,支气管哮喘等是常见病,多发病,慢性气管炎和支气管哮喘还可以发展成为肺气肿和肺原性心脏病,危害严重。某些化学介质,包括组胺,SRS-A,前列腺素类,缓激肽,嗜酸性细胞趋化因子(ECF-A)等,在哮喘发病中起了极其重要的作用。本文根据国内、外的研究进展,对SRS-A作进一步综述。一、SRS-A的作用 SRS-A最早发现于致敏豚鼠肺灌注液中,相继在致敏豚鼠的心肺装置中亦有发现。目前的研究指出,SRS-A不仅出现在过敏性休克或受抗原攻击的人和动物的肺组
Respiratory diseases such as colds, bronchitis, bronchial asthma and other diseases are common, frequently-occurring disease, chronic bronchitis and bronchial asthma can also develop into emphysema and pulmonary heart disease, serious harm. Some chemical mediators, including histamine, SRS-A, prostaglandins, bradykinin, and eotaxin (ECF-A), play an extremely important role in the pathogenesis of asthma. Based on the research progress at home and abroad, this article further reviews SRS-A. First, the role of SRS-A SRS-A was first found in the lungs of sensitized guinea pig perfusion fluid, one after another in the sensitized guinea pig heart-lung device were also found. Current research indicates that SRS-A is not only found in the lungs of anaphylactic shock or human and animal challenged with antigen