目的:探讨胆固醇线粒体转运蛋白对脂肪肝细胞模型糖脂代谢、炎症反应及其胰岛素敏感性的作用及其机制。方法:1.32mmol/L油酸+0.66 mmol/L软脂酸共同作用小鼠原代肝细胞建立脂肪肝细胞模型,携带St AR基因的腺病毒转染细胞得到St AR高表达组。Real-time PCR和Western blot检测糖脂代谢、炎症反应相关分子的变化;相关试剂盒检测肝细胞内甘油三酯、 Objective: To investigate the effect and mechanism of cholesterol mitochondrial transporter on glucose and lipid metabolism, inflammatory response and insulin sensitivity in fatty liver cell model. Methods: Fatty hepatocyte model was established by co-acting mouse primary hepatocytes with 1.32 mmol / L oleic acid and 0.66 mmol / L palmitate. St AR-expressing adenovirus-transfected cells were obtained. Real-time PCR and Western blot were used to detect the changes of glucose and lipid metabolism and inflammation related molecules. The relevant kit was used to detect the intracellular triglyceride,