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目的:分析拟行辅助生殖技术夫妇的染色体核型异常情况并探讨行染色体检查的必要性,为此类患者遗传咨询及辅助生殖技术的选择提供依据。方法:收集天津医科大学总医院近15年拟行IVF/ICSI-ET并行染色体核型分析的2621例患者,其中男性患者1365例,女性患者1256例。女性患者中无流产史573例,1次流产史446例,≥2次流产史237例。采用染色体G显带技术进行核型分析。结果:2621例患者中发现染色体异常71例,异常率为2.71%,其中男性35例(2.56%),女性36例(2.87%),染色体多态性率为4.85%。女性患者中有流产史组的染色体异常率与无流产史组比较,差异无统计学意义。结论:拟行辅助生殖技术人群中染色体异常率较高,建议行辅助生殖技术前常规行染色体检查。
OBJECTIVE: To analyze the anomalies of chromosomal karyotypes in couples assisted by assisted reproductive technology and to explore the necessity of performing chromosomal tests to provide basis for the genetic counseling and assisted reproductive technology selection of such patients. Methods: Totally 2621 patients were enrolled in Tianjin Medical University General Hospital in the past 15 years for IVF / ICSI-ET parallel karyotype analysis, including 1365 males and 1256 females. There were 573 cases of abortion in female patients, 446 cases of primary abortion, and 237 cases of ≥2 abortion. Karyotype analysis using chromosome G banding technique. Results: Of the 2621 patients, 71 cases were found chromosomal abnormalities with an abnormality rate of 2.71%, including 35 males (2.56%) and 36 females (2.87%) with a chromosome polymorphism rate of 4.85%. There was no significant difference in the rate of chromosomal abnormalities among women with abortion history group and without abortion history group. Conclusion: There is a high rate of chromosomal abnormalities in the assisted reproductive technology population. It is recommended to perform routine chromosomal tests before assisted reproductive technology.