巨细胞癌是罕见的高度恶性的肺部肿瘤,也可侵犯喉。本文报道4例均男性,55～64岁。除第1例少量吸烟外,其余每天吸烟20～30支;3例嗜酒,每天0.5～1升。肿瘤位于会厌,杓会厌襞至喉室,声带间。失语3例,呼吸困难2例,局部淋巴结转移3例。第1例无转移,部分喉切除术后随访6年存活。第2例水平部分喉切除术加放疗,后又行全喉切除术,6个月后死亡。第3例全喉切除术加放疗,12个月后死亡。第4例会厌切除和颈淋巴结切除术,术后放疗4个月后死亡。肉眼观察巨细胞癌与鳞癌无异。显微镜下所见与 Giant cell carcinoma is a rare, highly malignant lung tumor that can also invade the larynx. This article reported that 4 cases were all male, 55 to 64 years old. Except for a small amount of smoking in the first case, the rest smoked 20 to 30 cigarettes per day; 3 alcohol abusers, 0.5 to 1 litre per day. The tumor is located in the epiglottis, and the epiglottis dispels into the larynx and vocal cords. There were 3 cases of aphasia, 2 cases of dyspnea, and 3 cases of regional lymph node metastases. In the first case, there was no metastasis and partial laryngectomy survived after 6 years of follow-up. In the second case, partial laryngectomy followed by radiotherapy followed by total laryngectomy resulted in death after 6 months. The third case of total laryngectomy plus radiotherapy died 12 months later. The fourth epiglottic resection and cervical lymph node dissection was performed and died 4 months after radiotherapy. Visual observation of giant cell carcinoma is the same as squamous cell carcinoma. Seen under the microscope