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目的:对CT引导下经皮肺穿刺多电极高温射频消融治疗肺转移瘤的有效性和安全性进行研究评价。方法:对34例206个不同病理类型的肺转移瘤行多电极高温射频消融治疗,观察治疗过程中血压、脉搏和周围血氧饱和度的变化;治疗前后肝肾、肺功能的改变;以及CT扫描肿瘤组织中低密度影和肿瘤体积的变化。结果: 34例肺转移瘤患者多电极高温射频消融治疗中血压、脉搏和周围血氧饱和度无明显改变;治疗后肝肾功能、肺功能无明显影响;治疗后1个月内CT扫描见肿瘤体积较术前有所增大, 3个月后206个肿瘤中出现CR46个(100%缩小),PRa107个(80% ~100%缩小),PRb49个(50%~80%缩小),NR4个(缩小<50% );治疗后第3个月肿瘤内低密度影Ⅰ型6个,Ⅱ型86个,Ⅲ型114个。结论:多电极高温射频消融治疗肺转移瘤创伤小,近期效果好,比较安全,可能为临床提供了一种新的安全有效的治疗方法。
OBJECTIVE: To evaluate the efficacy and safety of multi-electrode radiofrequency ablation (RFA) guided by CT guided pulmonary metastases. Methods: 34 cases of 206 different pathological types of lung metastases were treated with multi-electrode radiofrequency ablation. The changes of blood pressure, pulse and peripheral oxygen saturation during treatment were observed. The changes of liver, kidney and lung function before and after treatment were observed. CT Scan tumor tissue low density changes and tumor volume changes. Results: There was no significant change of blood pressure, pulse rate and peripheral oxygen saturation in multi-electrode radiofrequency ablation of 34 patients with pulmonary metastases. There was no significant effect of liver and kidney function and pulmonary function after treatment; CT scan of tumor was found within 1 month after treatment The volume of the tumor was increased from the preoperative level. CR46 (100% reduction), PRa 107 (80% -100% reduction), PRb49 (50% -80% reduction), NR4 (Reduced <50%). In the third month after treatment, there were 6 type Ⅰ, 86 type Ⅱ and 114 type Ⅲ tumors. Conclusion: Multi-electrode radiofrequency ablation for the treatment of lung metastases with minimal trauma has good effect and safety in the near future, which may provide a new safe and effective method for clinical treatment.