对昂丹司琼致QT间期延长的研究进展进行了综述,分析了可能存在的机理。昂丹司琼可显著延长QTc间期,并可能因此而产生严重的心血管不良反应。其作用机制可能与昂丹司琼阻断心脏有关钠离子和钾离子通道,剂量依赖性地延长心脏复极化动作电位时程有关。昂丹司琼是光学异构体,其中R-昂丹司琼不引起QT间期的延长,而不影响疗效。 The research progress on the extension of QT interval caused by ondansetron was reviewed, and the possible mechanism was analyzed. Ondansetron significantly prolongs the QTc interval and may result in serious cardiovascular adverse events. Its mechanism may be related to the ondansetron block heart-related sodium and potassium channels, and dose-dependently prolong cardiac repolarization action potential duration. Ondansetron is an optical isomer, where R-ondansetron does not cause an extension of the QT interval without affecting the efficacy.