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代谢组学是继基因组学、转录组学、蛋白质组学之后系统生物学的主要研究平台,并逐渐成为生命科学的研究热点。在辅助生殖技术(assisted reproductive technology,ART)领域,卵泡液代谢组学已取得较大进展。目前,国内外大多数回顾性研究表明卵泡液相关代谢物(糖类、脂肪酸、氨基酸、激素等)可预测卵母细胞发育潜能,但有待大样本、多中心随机对照试验进一步证实。卵泡液代谢组学的深入研究有望成为评估卵母细胞质量并改善ART治疗结局的重要方法和手段。
Metabolomics is a major research platform of system biology after genomics, transcriptomics and proteomics, and has gradually become a research hotspot in life sciences. In the field of assisted reproductive technology (ART), great progress has been made in follicular fluid metabonomics. At present, most retrospective studies both at home and abroad show that follicular fluid related metabolites (carbohydrates, fatty acids, amino acids, hormones, etc.) can predict oocyte developmental potential, but large sample and multi-center randomized controlled trials further confirm. In-depth study of follicular fluid metabonomics is expected to be an important method and means to assess the quality of oocytes and improve the outcome of ART.