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目的:设计与合成rhBMP2新型控释载体,初步探讨其载药及降解性能。方法:用右旋糖酐 (dextran,dex)与甲基丙烯酸缩水甘油酯(glycidylmethacrylate,GMA)合成甲基丙烯酸缩水甘油酯右旋糖酐 (dex GMA),测定该凝胶微球溶胀系数Q,并对其载药、降解性能进行初步研究。结果:dex GMA在一定条件下可以成球,粒径与制备工艺密切相关;该凝胶微球溶胀参数 10. 9±5. 3;载药性能良好,在葡聚糖酶的作用下 20~40d内可以完全降解。结论:右旋糖酐基凝胶微球具有良好的溶胀性能,可生物降解,其粒径可控,作为生长因子载体,有望达到控释给药的目的,其制备工艺及理化性能有待进一步研究。
OBJECTIVE: To design and synthesize a novel controlled release carrier of rhBMP2 and to study its drug loading and degradation properties. Methods: dex GMA was synthesized by dextran dex and glycidylmethacrylate (GMA). The swelling coefficient Q of the gel microspheres was determined. The drug loading, Degradation performance of a preliminary study. Results: The dex GMA could be formed into pellets under certain conditions. The particle size was closely related to the preparation process. The swelling parameter of the gel microspheres was 10. 9 ± 5. 3. The drug loading properties were good. Under the action of dextranase, 40d can be completely degraded. CONCLUSION: Dextran-based gel microspheres have good swelling properties, are biodegradable, and their particle size is controlled. As a carrier of growth factor, dextran-based gel microspheres are expected to reach the goal of controlled release drug delivery. The preparation technology and physical and chemical properties of dextran-based gel microspheres are yet to be further studied.