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目的:通过对2007年-2016年9月在江川区人民医院住院分娩的17783例围产儿进行出生缺陷监测,10年来发生围产儿缺陷228例,发生缺陷率为12.82‰,探讨分析降低出生缺陷的干预措施。方法:对2012年-2016年9月出生的围产儿施行系统产前检查、孕中期产前血清学筛查和规范的孕中期产前B超检查排除胎儿畸形为观察组;与2007-2011月出生的围产儿施行系统产前检查但未进行孕中期产前血清学筛查,也没有严格进行B超排查的围产儿为对照组。结果:孕中期产前血清学筛查和规范B超检查发现的胎儿畸形逐年增多并及时引产,死胎发生率逐年减少,严重唇、腭裂、先天脑积水、无脑儿、脊柱裂、严重先天性心脏病、唐氏综合症活产儿明显降低,大大降低了新生儿活产出生缺陷率。
OBJECTIVE: To monitor birth defects in 17 783 perinatal infants hospitalized in People’s Hospital of Jiangchuan District from 2007 to September 2016. In the past 10 years, 228 cases of perinatal defects occurred, with a defect rate of 12.82 ‰, to explore the possibility of reducing birth defects Interventions. Methods: The system of prenatal examination, prenatal serological screening in the second trimester and prenatal B-mode prenatal B ultrasound examination were performed to exclude the fetus deformity as the observation group from 2012 to 2016 in September. Birth perinatal system for prenatal care but did not conduct prenatal serological screening during the second trimester, nor strict perinatal B ultrasound screening for the control group. Results: Prenatal serological screening and standardized B-mode ultrasound examination revealed that fetus deformity increased year by year and induction of labor in time, the incidence of stillbirth decreased year by year, severe lip, cleft palate, congenital hydrocephalus, anencephaly, spina bifida, severe congenital Sexual heart disease, Down’s syndrome, live births significantly reduced, greatly reducing birth defects in neonates live births.