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目的 :研究藻酸双酯钠 (PSS)治疗急性脑梗死 (ACI)的临床疗效和血浆生物分子的变化。方法 :随机选择临床确诊的ACI 98例 ,分成 3组 ,分别给予PSS ,胰岛素和三七总皂苷治疗。观察临床疗效和检测治疗前后病人的血脂、血糖 (Glu)、内皮素(ET 1)、P 选择素 (P selec)、血管内皮生长因子(VEGF)和血小板活化因子 (PAF)的变化。结果 :3组总有效率分别为 94 % ,96 % ,96 % ,经Ridit分析 ,疗效比较差异无显著意义 (P >0 .0 5 )。治疗后PSS组TG ,TC ,Glu ,ET 1,P selec和PAF值分别为(1.1± 0 .4 )mmol·L- 1,(4.2± 0 .7)mmol·L- 1,(7.2± 2 .3)mmol·L- 1,(33± 4 )ng·L- 1,(2 9± 4 )μg·L- 1和 (6 0± 14 ) μg·L- 1较治疗前明显降低 ,差异有显著和非常显著意义 (P <0 .0 5和 0 .0 1) ;PSS组与RI组或三七总皂苷组血糖组间比较 ,差异有非常显著意义 (P <0 .0 1)。结论 :PSS治疗ACI的临床疗效与胰岛素 ,三七总皂苷相似 ,但对血浆生物分子学的改变则有显著差别。
Objective: To study the clinical efficacy and changes of plasma biomolecules of sodium alginate (PSS) in the treatment of acute cerebral infarction (ACI). Methods: A total of 98 cases of clinically diagnosed ACI were randomly divided into three groups, which were treated with PSS, insulin and total saponins of Panax notoginseng. To observe the clinical curative effect and the changes of blood lipid, blood glucose (Glu), endothelin (ET 1), Pselec, vascular endothelial growth factor (VEGF) and platelet activating factor (PAF) in patients before and after treatment. Results: The total effective rates of the three groups were 94%, 96% and 96%, respectively. Ridit analysis showed no significant difference (P> 0.05). The levels of TG, TC, Glu, ET 1, P selec and PAF in PSS group after treatment were (1.1 ± 0.4) mmol·L -1, (4.2 ± 0. 7) mmol·L -1, (7.2 ± 2) .3) mmol·L-1, (33 ± 4) ng · L-1, (29 ± 4) μg · L-1 and (60 ± 14) μg · L-1 were significantly lower than those before treatment, (P <0.05 and 0.01). There was a significant difference between the PSS group and the RI group or the Panax notoginseng glycosides group (P <0.01). Conclusion: The clinical efficacy of PSS in the treatment of ACI is similar to that of insulin and total saponins of Panax notoginseng, but there are significant differences in the changes of plasma biomolecules.