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塞来昔布是一个环氧化酶 2 (COX 2 )特异性抑制剂 ,是治疗骨关节炎和类风湿关节炎的抗炎镇痛药 ,而伴随治疗的不良作用则是由于其对COX 1的抑制作用。临床试验表明 :塞来昔布较安慰剂明显有效 ,且与传统NSAID的萘普生疗效相当 ,安全且耐受性好 ,不影响血小板聚集 ,也未出现胃肠道溃疡。
Celecoxib is a specific inhibitor of cyclooxygenase 2 (COX 2) and is an anti-inflammatory and analgesic for the treatment of osteoarthritis and rheumatoid arthritis. Concomitant treatment is due to its effect on COX 1 Inhibition. Clinical trials have shown that celecoxib is significantly more effective than placebo and comparable in efficacy to naproxen with traditional NSAIDs, safe and well tolerated, does not affect platelet aggregation, and does not cause gastrointestinal ulceration.