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目的:研究三七复方纳米颗粒剂抑制血栓形成作用并探讨其作用机制。方法:建立电刺激致大鼠血栓模型,观察三七复方纳米颗粒剂抗血栓作用以及对血液流变学的影响;建立肾上腺素加冰浴致大鼠血瘀模型,观察其对血栓素A2(TXA2)和前列环素I2(PG I2)的影响。结果:与对照组比较,给予三七复方纳米颗粒剂各剂量组以及阿司匹林组均能明显延长电刺激所致动脉血栓的形成时间,降低血液黏度,显著升高血瘀模型大鼠血浆中6-酮-前列环素F1α(6-Keto-PGF1α)的含量(P<0.01)和6-Keto-PGF1α/TXB2值(P<0.01),降低TXB2的含量(P<0.05)。结论:三七复方纳米颗粒剂具有抗血栓作用,其作用机制与降低血液黏度和改变PG I2/TXA2比值有着密切的关系。
Objective: To study the inhibitory effect of Panax notoginseng compound nanoparticles on thrombosis and its mechanism. Methods: Thrombus model induced by electrical stimulation was established in rats. The antithrombotic effect of Panax notoginseng compound nanoparticles and the effect on hemorrheology were observed. The blood stasis model induced by epinephrine plus ice bath was established. TXA2) and prostacyclin I2 (PG I2). Results: Compared with the control group, each dose of Panax notoginseng group and aspirin group could prolong the formation time of arterial thrombosis induced by electrical stimulation, reduce the blood viscosity and significantly increase the plasma levels of 6- Keto-PGF1α (P <0.01) and 6-Keto-PGF1α / TXB2 (P <0.01) decreased the content of TXB2 (P <0.05). Conclusion: Panax notoginseng compound nanoparticles have antithrombotic effect. Its mechanism of action is closely related to the decrease of blood viscosity and the change of PG I2 / TXA2 ratio.