论文部分内容阅读
用改良气相色谱法观察了黑索金，氯乙烯职业接触者及急、慢性肝病、肝癌等血清胆汁酸的变化，发现２种亲肝性毒物致肝损害时胆汁酸变化不同；黑索金组血清石胆酸（ＬＣＡ）、脱氧胆酸（ＤＣＡ）、鹅脱氧胆酸（ＣＤＣＡ）升高，显著性检验有差异；氯乙烯组只有ＬＣＡ、ＤＣＡ升高；变化主要集中在次级胆汁酸。急、慢性肝炎、肝硬化、肝癌等肝损害时血清ＬＣＡ、ＤＣＡ、ＣＤＣＡ和胆酸（ＣＡ）有不同程度升高，以ＣＤＣＡ、ＣＡ变化明显，差异有统计学意义；但比较四种胆汁酸水平的变化无显著性差异，而ＣＡ／ＣＤＣＡ值互有不同，差异有统计学意义。提示血清胆汁酸可用于诊断，鉴别诊断各型肝炎，为临床提供了科学依据。
The changes of serum bile acids in desloratadine, vinyl chloride occupational exposure and acute and chronic liver diseases, liver cancer and other serum were observed by modified gas chromatography. The changes of bile acids were different between the two kinds of hepatotoxic agents. Serum LCA, DCA and CDCA increased, and there was significant difference between the two groups. Only LCA and DCA increased in VCG group; the changes were mainly in sub-bile acid group. Serum levels of LCA, DCA, CDCA and cholic acid (CA) were increased to different extents in acute and chronic hepatitis, cirrhosis, liver cancer and other liver damage, with significant changes in CDCA and CA, the difference was statistically significant; but compared four kinds of bile acids There was no significant difference in the level of change, while the value of CA / CDCA was different from each other, the difference was statistically significant. Tip serum bile acid can be used for diagnosis, differential diagnosis of various types of hepatitis, providing a scientific basis for clinical.